Aggressive chemicals can present significant sealing challenges even at low temperatures and pressures. Chemicals can degrade the sealing element, pipe bore, and flange face, eventually compromising joint integrity. The consequences of chemical leaks can be severe, particularly when dealing with toxic, corrosive or flammable media.

To minimise seal degradation, gasket materials must be chemically compatible, and capable of performing at the specified temperature, pressure and chemical concentration. For applications where use of conventional metalagy is not possible, the use of glass, plastic, or lined pipework is commonplace. This can place additional demands on the seal, for instance, assembly loads may be limited and smooth sealing faces can give rise to enhance gasket creep and blow out failure.